Gem‐Difluorination of Triazole Alkyl Functionalized Amino Pyrazoles by Selectfluor to Access 4, 4‐Difluoro‐pyrazol‐3‐ones/Pyrazol‐3‐imines. Issue 13 (21st March 2019)

• Record Type: Journal Article
• Authors: Srikanth Reddy, Narra; Ravi Kumar, Nagiri; Krishna Swaroop, Desireddy; Punna, Nagender; Jitender Dev, Gaddameedi; Jagadeesh Babu, Nanubolu; Narsaiah, Banda
• Is Part Of: European journal of organic chemistry. Issue 13(2019)
• Page Start: 2409
• Page End: 2413
• Publication Date: 2019-03-21
• Subjects: Triazoles -- C–H halogenation -- Electrophilic substitution -- Gem‐difluorination -- Selectfluor; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201900173
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : We have successfully accomplished gem ‐difluorination of triazole alkyl functionalized amino pyrazoles in the presence of Selectfluor under dry condition and obtained 4, 4‐difluoro pyrazol‐3‐imines derivatives in high yield. However, in the presence of water, 4, 4‐difluoro pyrazol‐3‐one derivatives were afforded. Abstract : Gem ‐difluorination of triazole alkyl functionalized amino pyrazoles was successfully accomplished in the presence of Selectfluor under dry condition and 4, 4‐difluoro pyrazol‐3‐imines derivatives were obtained in high yield.