Imidazo‐Fused Isoindoles by Pd(II)/Ag(I)‐Promoted Intramolecular Dehydrogenative Coupling. Issue 7 (10th February 2020)

• Record Type: Journal Article
• Authors: Lessi, Marco; Lucci, Antonio; Cuzzola, Angela; Bellina, Fabio
• Is Part Of: European journal of organic chemistry. Issue 7(2020)
• Page Start: 796
• Page End: 802
• Publication Date: 2020-02-10
• Subjects: C–H activation -- Palladium -- Cross‐coupling -- Isoindoles -- Arylation; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201901618
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : An effective Pd(II)/Ag(I)‐promoted intramolecular cross‐dehydrogenative coupling (CDC) of substituted 1‐benzylimidazoles under air provides, for the first time, a simple access to several functionalized imidazo[2, 1 ‐a ]isoindoles, an interesting class of polycyclic heteroaromatic compounds. The direct involvement of two unactivated carbon–hydrogen bonds, without any directing group, grants an elevated atom economy of the whole process. Abstract : Several imidazo[2, 1‐ a ]isoindoles, an interesting class of polycyclic heteroarenes, were prepared, for the first time, by a Pd(II)/Ag(I)‐promoted intramolecular cross‐dehydrogenative coupling involving the corresponding 1‐benzylimidazoles.