Commercial Cannabinoid Oil-Induced Stevens-Johnson Syndrome. (20th February 2020)

• Record Type: Journal Article
• Authors: Yin, Han Y.; Hadjokas, Nicholas; Mirchia, Kanish; Swan, Robert; Alpert, Samuel
• Other Names: Hayashi Takaaki Academic Editor.
• Is Part Of: Case reports in ophthalmological medicine. Volume 2020(2020)
• Publication Date: 2020-02-20
• Subjects: Ophthalmology -- Periodicals; Eye -- Diseases -- Periodicals; Ophthalmology; Eye Diseases; Eye -- Diseases; Ophthalmology; Electronic journals; Periodicals; Periodicals; Case Reports; Fulltext; Internet Resources; Periodicals; 617.7
• DOI: 10.1155/2020/6760272
• Languages: English
• ISSNs: 2090-6722

Abstract

Abstract : Purpose . To report an unusual presentation of commercial cannabidiol (CBD) oil-induced Stevens-Johnson Syndrome/toxic epidermal necrolysis (SJS-TEN). Methods . A 56-year-old woman presented with acute onset of a diffuse, blistering, maculopapular rash with over 30% total body surface area (BSA) involvement two days after taking CBD oil sublingually for chronic pain. Biopsy confirmed SJS-TEN. Ophthalmology was consulted and mild eye involvement was found. She was started on topical cyclosporine, prednisone, moxifloxacin, and erythromycin ointment to prevent progression, which was successful. She was otherwise treated with supportive therapy in the intensive care burn unit and ultimately passed away from septic shock. Conclusion . In this case, we described an unusual drug-induced SJS from a commercial, non-FDA-regulated cannabis product. The use of a commercial CBD product should be cautioned due to potential for series of drug reactions to the cannabis product and the risk for reaction to other unregulated other pharmacological components.