Biomaterials Containing the Natural Antioxidant Quercetin: Synthesis and Health Benefits. Issue 1 (20th February 2020)

• Record Type: Journal Article
• Authors: Pacifico, Severina; Piccolella, Simona; Barrino, Federico; Catauro, Michelina
• Editors: Grassia, Luigi; Lamanna, Giuseppe
• Is Part Of: Macromolecular symposia. Volume 389:Issue 1(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-02-20
• Subjects: antioxidant activity -- bioactivity -- intracellular reactive oxygen species -- quercetin -- sol–gel hybrid materials; Macromolecules -- Congresses; Polymers -- Congresses; Polymerization -- Congresses; Macromolecules -- Periodicals; Polymers -- Periodicals; Polymerization -- Periodicals; 547.705
• DOI: 10.1002/masy.201900060
• Languages: English
• ISSNs: 1022-1360

Abstract

Abstract: Quercetin, whose health‐promoting effects are acclaimed, is entrapped in a silica‐based and silica/polymer hybrid material via sol–gel route, to develop new antioxidant biomaterials for preventing the onset of ROS‐related diseases. The materials' morphology is detected by SEM analysis, whereas the chemical characterization is achieved by spectroscopic and spectrometric techniques. Despite an oxidation reaction in the quercetin structure, DPPH (2, 2‐diphenyl‐1‐picrylhydrazyl) and ABTS [2, 2′‐azinobis‐(3‐ethylbenzothiazolin‐6‐sulfonic acid)] data show that all the materials preserve its antioxidant efficacy. MTT [3‐(4, 5‐dimethyl‐2‐thiazolyl)‐2, 5‐diphenyl‐2H‐tetrazolium bromide] test indicates a mild cytotoxicity in NIH‐3T3, PC12, and U251 cells. Furthermore, materials with the highest quercetin percentage are able to inhibit the H2 O2 ‐induced intracellular ROS production in murine fibroblasts.