Design and Synthesis of ZnII‐Coordination Polymers Anchored with NSAIDs: Metallovesicle Formation and Multi‐drug Delivery. Issue 4 (22nd January 2020)

• Record Type: Journal Article
• Authors: Bera, Sourabh; Chowdhury, Abhinanda; Sarkar, Koushik; Dastidar, Parthasarathi
• Is Part Of: Chemistry, an Asian journal. Volume 15:Issue 4(2020)
• Page Start: 503
• Page End: 510
• Publication Date: 2020-01-22
• Subjects: biological activity -- combination therapy -- Coordination polymers -- metallovesicle -- multi-drug delivery -- NSAIDs -- self-assembly; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/asia.201901664
• Languages: English
• ISSNs: 1861-4728

Abstract

Abstract: A series of coordination polymers synthesized from a bis‐pyridyl linker, namely 4, 4′‐azopyridine (L ), selected non‐steroidal‐anti‐inflammatory drugs (NSAIDs), namely diclofenac (Dic ), ibuprofen (Ibu ), flurbiprofen (Flu ), mefenamic acid (Mefe ), and naproxen (Nap ), and Zn(NO3 )2 were characterized by single crystal X‐ray diffraction. One of the coordination polymers, namely CP3 derived from Flu, was able to form metallovesicles in DMSO, DMSO/H2 O and DMSO/DMEM (biological media) as revealed by TEM, AFM and DLS. Metallovesicle formation by CP3 was further supported by loading a fluorescent dye, namely calcein, as well as an anti‐cancer drug, doxorubicin hydrochloride (DOX ), as revealed by UV‐vis and emission spectra, and fluorescence microscopy. DOX ‐loaded metallovesicles of CP3 (DOX@CP3‐vesicle ) could be delivered in vitro to a highly aggressive human breast cancer cell line, namely MDA‐MB‐231, as revealed by MTT and cell migration assays, and also cell imaging performed under laser scanning confocal microscope (LSCM). Thus, a proof of concept for developing a multi‐drug delivery system derived from a metallovesicle for delivering an anti‐cancer drug to cancer cells is demonstrated for the first time. Abstract : A proof of the concept for developing multi‐drug delivery systems from a metallovesicle derived from a coordination polymer has been demonstrated.