Novel Tragacanth Gum-Entrapped lecithin nanogels for anticancer drug delivery. Issue 9 (12th June 2020)

• Record Type: Journal Article
• Authors: Verma, Chetna; Negi, Poonam; Pathania, Deepak; Anjum, Sadiya; Gupta, Bhuvanesh
• Is Part Of: International journal of polymeric materials. Volume 69:Issue 9(2020)
• Page Start: 604
• Page End: 609
• Publication Date: 2020-06-12
• Subjects: Cisplatin -- lecithin -- nanoemulsion -- nanogel -- tragacanth gum; Polymers -- Periodicals; Plastics -- Periodicals; 620.19205
• DOI: 10.1080/00914037.2019.1596910
• Languages: English
• ISSNs: 0091-4037

Abstract

Abstract: Nanogels are functional particles that may be used to deliver bioactive molecules in targeted drug delivery systems. In the present work, we have investigated the preparation of cisplatin (CP) loaded Tragacanth Gum (TG)-lecithin (LC) nanogels by nanoemulsion process. These nanogels exhibit polygonal core-shell structure in which CP particles are embedded in the TG core of the nanogels and remain covered by LC as shell. Varying concentration of CP were added in the nanogel and the shape and size of the nanogels was investigated. Nanogels were characterized by dynamic light scattering analysis as well. Sustained release of CP from the CP-loaded nTG-LC nanogels as drug was observed in controlled manner under physiological saline. Graphical Abstract: