Intravenous immunoglobulin suppresses the polarization of both classically and alternatively activated macrophages. Issue 2 (1st February 2020)

• Record Type: Journal Article
• Authors: Saha, Chaitrali; Kothapalli, Prathap; Patil, Veerupaxagouda; ManjunathaReddy, Gundallahalli Bayyappa; Kaveri, Srini V; Bayry, Jagadeesh
• Is Part Of: Human vaccines & immunotherapeutics. Volume 16:Issue 2(2020)
• Page Start: 233
• Page End: 239
• Publication Date: 2020-02-01
• Subjects: IVIG -- macrophage -- inflammation -- monocyte -- innate cells -- IgG; Vaccines -- Periodicals; 615.372
• DOI: 10.1080/21645515.2019.1602434
• Languages: English
• ISSNs: 2164-5515

Abstract

ABSTRACT: Intravenous immunoglobulin (IVIG) is one of the widely used immunotherapeutic molecules in the therapy of autoimmune and inflammatory diseases. Previous reports demonstrate that one of the anti-inflammatory actions of IVIG implicates suppression of macrophage activation and release of their inflammatory mediators. However, macrophages are highly plastic and depending on the microenvironmental signals, macrophages can be polarized into pro-inflammatory classic (M1) or anti-inflammatory alternative (M2) type. This plasticity of macrophages raised additional questions on the role of IVIG towards macrophage polarization. In the present report, we show that IVIG affects the polarization of both classically and alternatively activated macrophages and this process is F(ab')2 -independent. Our data thus indicate the lack of reciprocal regulation of inflammatory and non-inflammatory macrophages by IVIG.