Analyses of the 2019 Nobel Prize in Physiology or Medicine: Molecular Machinery for Cellular Oxygen Level Response. Issue 1 (2nd January 2020)

• Record Type: Journal Article
• Authors: Gilman, Neyda V.
• Is Part Of: Science & technology libraries. Volume 39:Issue 1(2020)
• Page Start: 1
• Page End: 27
• Publication Date: 2020-01-02
• Subjects: Kaelin -- Ratcliffe -- Semenza -- oxygen -- HIF -- VHL -- Nobel; Science and technology libraries -- Periodicals; Wetenschappelijke bibliotheken; Natuurwetenschappen; Techniek; Sciences -- Bibliothèques -- Périodiques; Technologie -- Bibliothèques -- Périodiques; Ressource Internet (Descripteur de forme); Périodique électronique (Descripteur de forme); 026.5
• DOI: 10.1080/0194262X.2019.1703875
• Languages: English
• ISSNs: 0194-262X

Abstract

ABSTRACT: Gregg L. Semenza, William G Kaelin, Jr, and Sir Peter J. Ratcliffe were awarded the 2019 Nobel Prize for Physiology or Medicine on October 7, 2019. Their work led to the understanding of how cells recognize and adapt to varying oxygen levels. Hypoxia-inducible nuclear factors play an essential role in this mechanism by turning on other genes that work toward increasing oxygen levels in hypoxic environments. Other vital pieces of the machinery include von Hippel-Lindau proteins and prolyl hydroxylation. Due to the necessity of oxygen in numerous human physiological systems, this discovery will likely have nearly immeasurable impacts on human health.