Anti-inflammatory activity of 4′, 6, 7-trihydroxy-5-methoxyflavone from Fridericia chica (Bonpl.) L.G.Lohmann. Issue 5 (3rd March 2020)

• Record Type: Journal Article
• Authors: Lima, Joaquim C. S.; de Oliveira, Ruberlei Godinho; Silva, Virgínia C.; de Sousa Jr, Paulo Teixeira; Violante, Ivana M. P.; Macho, Antonio; Martins, Domingos Tabajara de Oliveira
• Is Part Of: Natural product research. Volume 34:Issue 5(2020)
• Page Start: 726
• Page End: 730
• Publication Date: 2020-03-03
• Subjects: Fridericia chica -- Arrabidaea chica -- leaf extract -- cytotoxicity -- anti-inflammatory activity -- 4′, 6, 7-trihydroxy-5-methoxyflavone -- 5-O-methylscutellarein; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1495636
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Fridericia chica, Bignoniaceae, is a tropical tree-creeper used as a traditional remedy for a number of diseases, highlighting inflammation. Our objective was to corroborate the popular anti-inflammatory use of the hydroethanolic extract from the leaves (HEFc) and of its isolated 4′, 6, 7-trihydroxy-5-methoxyflavone (5- O -methylscutellarein) [1 ], described here for the first time. Quantitative analysis indicated 8.77 ± 0.23 mg/g of this compound in the extract. Neither HEFc nor [1 ] was cytotoxic in vitro . In LPS-induced peritonitis in mice, oral pre-treatment with HEFc or [1 ] led to decreased leukocyte migration to the peritoneal cavity and a reduction in the concentrations of pro-inflammatory cytokines (TNFα and IL-1β). Also, the anti-inflammatory cytokine IL-10 was enhanced following treatment with [1 ]. Overall, these results validate the traditional use of Fridericia chica as anti-inflammatory, and indicate that the compound 5- O -methylscutellarein may participate in this effect. Abstract :