Role of the Nox4/AMPK/mTOR signaling axe in adipose inflammation-induced kidney injury. (25th February 2020)

• Record Type: Journal Article
• Authors: Njeim, Rachel; Farhat, Theresa; Alkhansa, Sahar; Youssef, Natalie; Dia, Batoul; Slika, Rasha; Diab, Radwan; Azar, Sami T.; Eid, Assaad A.
• Is Part Of: Clinical science. Volume 134:Number 4(2020)
• Page Start: 403
• Page End: 417
• Publication Date: 2020-02-25
• Subjects: Adipose Inflammation -- Diabetes -- Diabetic Kidney Disease -- NADPH oxidase -- obesity -- Oxidative Stress; Medicine -- Periodicals; Biochemistry -- Periodicals; 616
• DOI: 10.1042/CS20190584
• Languages: English
• ISSNs: 0143-5221

Abstract

Abstract: Diabetic kidney disease is one of the most serious complications of diabetes worldwide and is the leading cause of end-stage renal disease. While research has primarily focused on hyperglycemia as a key player in the pathophysiology of diabetic complications, recently, increasing evidence have underlined the role of adipose inflammation in modulating the development and/or progression of diabetic kidney disease. This review focuses on how adipose inflammation contribute to diabetic kidney disease. Furthermore, it discusses in detail the underlying mechanisms of adipose inflammation, including pro-inflammatory cytokines, oxidative stress, and AMPK/mTOR signaling pathway and critically describes their role in diabetic kidney disease. This in-depth understanding of adipose inflammation and its impact on diabetic kidney disease highlights the need for novel interventions in the treatment of diabetic complications.