The role of cytochrome P4502E1 in the pathogenesis of alcoholic liver disease and carcinogenesis. (25th January 2020)

• Record Type: Journal Article
• Authors: Seitz, Helmut K.
• Is Part Of: Chemico-biological interactions. Volume 316(2020)
• Publication Date: 2020-01-25
• Subjects: Biochemistry -- Periodicals; Toxicological chemistry -- Periodicals; Biochemistry -- Periodicals; Biologie moléculaire -- Périodiques; Biochimie -- Périodiques; Toxicologie biochimique -- Périodiques; 572
• DOI: 10.1016/j.cbi.2019.108918
• Languages: English
• ISSNs: 0009-2797

Abstract

Highlights: Chronic alcohol ingestion induces cytochrome P4502E1. CYP-4502E1 activates procarcinogens, degradates retinoids and generates free radicals. Cytochrome P4502E1 is a pathogenic factor in alcoholic liver disease. Cytochrome P4502E1 is a pathogenic factor in alcohol mediated carcinogenesis. Inhibition of cytochrome P4502E1 improves alcoholic liver disease.