Asymmetric dearomatization of 2-nitrobenzofurans by organocatalyzed one-step Michael addition to access 3, 3′-disubstituted oxindoles. Issue 17 (4th February 2020)

• Record Type: Journal Article
• Authors: Ge, Zhen-Zhen; Yang, Lei; You, Yong; Wang, Zhen-Hua; Xie, Ke-Xin; Zhou, Ming-Qiang; Zhao, Jian-Qiang; Yuan, Wei-Cheng
• Is Part Of: Chemical communications. Volume 56:Issue 17(2020)
• Page Start: 2586
• Page End: 2589
• Publication Date: 2020-02-04
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc09939e
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An efficient enantioselective dearomatization of 2-nitrobenzofurans was realized by organocatalyzed one-step Michael addition to access structurally diverse 3, 3′-disubstituted oxindoles. Abstract : An efficient enantioselective dearomatization of 2-nitrobenzofurans was realized via an organocatalyzed one-step Michael addition process. This method provides a facile strategy to access a range of structurally diverse 3, 3′-disubstituted oxindoles, which feature an intriguing combination of two privileged motifs including 3-pyrrolyl-substituted-oxindoles and 2, 3-dihydrobenzofurans substructures, in excellent results.