Compact reaction-module on a pad for scalable flow-production of organophosphates as drug scaffolds. Issue 5 (30th January 2020)

• Record Type: Journal Article
• Authors: Yim, Se Jun; Ramanjaneyulu, Bandaru T.; Vidyacharan, Shinde; Yang, Yu Dong; Kang, In Seok; Kim, Dong-Pyo
• Is Part Of: Lab on a chip. Volume 20:Issue 5(2020)
• Page Start: 973
• Page End: 978
• Publication Date: 2020-01-30
• Subjects: Miniature electronic equipment -- Periodicals; Combinatorial chemistry -- Periodicals; Biotechnology -- Periodicals; 543.0813
• DOI: 10.1039/c9lc01099h
• Languages: English
• ISSNs: 1473-0197

Abstract

Abstract : Continuous pharmaceutical manufacturing receives intense attention as an alternative way to meet flexible market needs with the assurance of higher safety and quality control. Abstract : Continuous pharmaceutical manufacturing receives intense attention as an alternative way to meet flexible market needs with the assurance of higher safety and quality control. Here, we report a compact reaction-module on a pad (CRP, 170 × 170 × 1.2 mm) for scale-up production of drug precursors in a continuous-flow. The CRP system was devised by stacking 9 films of the patterned polyimide to integrate micro-flow circuits, combining the functions of the even distribution of feeds, being completely mixed in less than a few milliseconds. A methodology of using a highly reactive species for the single-step synthesis of α-phosphonyloxy ketone, a drug scaffold, required the synthesis time of a few seconds in microfluidics. The fast reaction in the single CRP was capable of producing 19.2 g h −1 drug precursor, which indicates a solid step toward kilogram-scale pharmaceutical manufacturing in small footage.