Chemical synthesis of human milk oligosaccharides: lacto-N-neohexaose (Galβ1 → 4GlcNAcβ1→)2 3, 6Galβ1 → 4Glc. Issue 9 (12th February 2020)

• Record Type: Journal Article
• Authors: Bandara, Mithila D.; Stine, Keith J.; Demchenko, Alexei V.
• Is Part Of: Organic & biomolecular chemistry. Volume 18:Issue 9(2020)
• Page Start: 1747
• Page End: 1753
• Publication Date: 2020-02-12
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob00172d
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : The first chemical synthesis of lacto- N -neohexaose (LNnH) has been completed using a convergent synthetic strategy. Abstract : The first chemical synthesis of lacto- N -neohexaose (LNnH) has been completed using a convergent synthetic strategy. The reaction conditions and donor–acceptor combinations have been carefully refined to minimize side reactions and achieve high yields in all glycosylation steps. Lacto- N -neotetraose, another common human milk oligosaccharide, was also synthesized en route to the target LNnH.