Preparation of cyclic imides from alkene-tethered amides: application of homogeneous Cu(ii) catalytic systems. Issue 13 (21st February 2020)

• Record Type: Journal Article
• Authors: Liu, Zhenghui; Wang, Peng; Ou, Hualin; Yan, Zhenzhong; Chen, Suqing; Tan, Xingxing; Yu, Dongkun; Zhao, Xinhui; Mu, Tiancheng
• Is Part Of: RSC advances. Volume 10:Issue 13(2020)
• Page Start: 7698
• Page End: 7707
• Publication Date: 2020-02-21
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c9ra10422d
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A catalytic system comprising Cu(ii ) and a nitrogen-based ligand for the oxygenation and cyclization of alkene-tethered amides. Abstract : A Cu-based homogeneous catalytic system was proposed for the preparation of imides from alkene-tethered amides. Here, O2 acted as a terminal oxidant and a cheap and easily available oxygen source. The cleavage of CC bonds and the formation of C–N bonds were catalyzed by Cu(ii ) salts with proper nitrogen-containing ligands under 100 °C. The synthesis approach has potential applications in pharmaceutical syntheses. Moreover, scaled-up experiments confirmed the practical applicability.