Compassionate Use of Letermovir in a 2-Year-Old Immunocompromised Child With Resistant Cytomegalovirus Disease. (11th June 2019)

• Record Type: Journal Article
• Authors: Pérez Marín, Maria; Decosterd, Laurent Arthur; Andre, Pascal; Buclin, Thierry; Mercier, Thomas; Murray, Kristina; Rizzi, Mattia; Meylan, Pascal; Jaton-Ogay, Katia; Opota, Onya; Gengler, Carole; Perez, Marie-Hélène; Natterer, Julia; Asner, Sandra Andrea
• Is Part Of: Journal of the Pediatric Infectious Diseases Society. Volume 9:Number 1(2020)
• Page Start: 96
• Page End: 99
• Publication Date: 2019-06-11
• Subjects: cytomegalovirus disease -- cytomegalovirus infection -- letermovir -- therapeutic drug monitoring; Communicable diseases in children -- Periodicals; Children -- Diseases -- Periodicals; 618.929
• DOI: 10.1093/jpids/piz033
• Languages: English
• ISSNs: 2048-7193

Abstract

Abstract: Little information on the efficacy and pharmacokinetics of letermovir among immunocompromised children is currently available. We describe here the use of letermovir in a 2-year-old immunocompromised child with ganciclovir-resistant cytomegalovirus disease who required extracorporeal membrane oxygenation. Detailed information on therapeutic-drug-monitoring measures and dosage adjustments for letermovir is provided.