Dairy-derived peptides for satiety. (March 2020)

• Record Type: Journal Article
• Authors: Kondrashina, Alina; Brodkorb, André; Giblin, Linda
• Is Part Of: Journal of functional foods. Volume 66(2020)
• Publication Date: 2020-03
• Subjects: Dairy-derived peptides -- Satiety -- Gastrointestinal hormones -- Gastrointestinal digestion -- Protein delivery systems; AA amino acid -- α-LA α-lactalbumin -- β-CM7 β-casomorphin-7 -- β-LG β-lactoglobulin -- BSA bovine serum albumin -- CCK cholecystokinin -- CMP caseinomacropeptide -- DPP-IV dipeptidyl peptidase-IV -- GCPR G-coupled protein receptors -- GI gastrointestinal -- GIP gastric inhibitory polypeptide -- GMP glycomacropeptide -- GLP-1 glucagon-like peptide-1 -- GRAS generally regarded as safe -- GRP gastrin releasing peptide -- GSPE grape-seed procyanidin extract -- Ig immunoglobulin -- I.p intraperitoneal -- Lf lactoferrin -- PYY peptide YY -- VAS visual analogue scale -- WPC whey proteinconcentrate -- WPI whey protein isolate -- WSE water soluble extract; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2020.103801
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: Casein peptides appear to predominantly target GLP-1, CCK secretion and DPP-IV. Whey peptides appear to influence CCK, serotonin and ghrelin pathways. Certain Dairy peptides that stimulate satiety signaling in vitro can reduce food intake in vivo. Abstract: Satiety hormones produced in the gastrointestinal tract are key players in influencing appetite and food intake. Dairy proteins that target these gastric signals have the potential to make one feel 'fuller for longer'. While effects of whey and casein on appetite and food intake are well documented, this review focuses on individual dairy peptides. The evidence of these peptide bioactives on satiety signaling in vitro using cellular models and in vivo via intervention trials is summarized. Dairy protein hydrolysates are also reviewed for their satiating properties. How their efficacy compares to other notable food derived peptides and how this efficacy can be lost, bolstered or protected during gut transit is also summarized.