The antitumor activity of Arthrospira platensis and/or cisplatin in a murine model of Ehrlich ascites carcinoma with hematinic and hepato-renal protective action. (March 2020)

• Record Type: Journal Article
• Authors: Hashem, Mohamed A.; Shoeeb, Sara B.A.; Abd-Elhakim, Yasmina M.; Mohamed, Wafaa A.M.
• Is Part Of: Journal of functional foods. Volume 66(2020)
• Publication Date: 2020-03
• Subjects: Arthrospira platensis -- Cisplatin -- Ehrlich ascites carcinoma -- Peritoneum -- Ki67 -- Caspase 3; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2020.103831
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: Spirulina (SP) has antitumor action in Ehrlich ascites carcinoma (EAC) bearing mice. SP potentiated cisplatin (CDDP) antitumor activity in EAC bearing mice. SP and or CDDP adjusted peritoneal Caspase-3 and Ki-67 immunoexpression. SP reduced CDDP induced hepato-renal damage. SP corrected CDDP - induced hematological and bone marrow alterations. Abstract: Herein two experiments were conducted. The first experiment evaluated the antitumor activity of Arthrospira platensis ( Spirulina platensis, SP) alone or in combination with cisplatin (CDDP) in Ehrlich ascites carcinoma (EAC) bearing mice. The second experiment assessed the outcomes of SP and/or CDDP administration on renal, hepatic, and bone marrow function in normal mice. The results showed that the EAC evoked a significant decrease in the mice survival rate, life span percentage, antioxidant defense system, and Caspase-3 immunoexpression but a significant increase in the viable cancer cells count, tumor and lipid peroxidation biomarkers concentrations, and Ki-67 immunoexpression. The EAC induced alterations improved to various degrees following SP and/or CDDP administration. SP minimized the oxidative hepatic and renal DNA-damaging and hematotoxic effect of CDDP. Overall, SP has a potent anticancer activity and could be used effectively as a hematinic and hepato-renal protective agent with anticancer drugs like CDDP.