Effect of transcatheter arterial embolisation in normal canine liver using trisacryl gelatine microspheres (Embosphere). (April 2020)

• Record Type: Journal Article
• Authors: Nakasumi, Ko; Sunahara, Hiroshi; Igari, Kazuaki; Itoh, Harumichi; Itamoto, Kazuhito; Yamamoto, Naoki; Ishikawa, Tsuyoshi; Takami, Taro; Sakaida, Isao; Taura, Yasuho; Tani, Kenji
• Is Part Of: Research in veterinary science. Volume 129(2020)
• Page Start: 174
• Page End: 177
• Publication Date: 2020-04
• Subjects: Transcatheter arterial embolisation -- Trisacryl gelatine microspheres -- Hepatocellular carcinoma; Veterinary medicine -- Periodicals; Veterinary Medicine -- Periodicals; Médecine vétérinaire -- Périodiques; Médecine vétérinaire -- Recherche -- Périodiques; Diergeneeskunde; 636.089
• DOI: 10.1016/j.rvsc.2020.01.018
• Languages: English
• ISSNs: 0034-5288

Abstract

Abstract: The effect of selective transcatheter arterial embolisation (TAE) using trisacryl gelatine microspheres (TGMs) in the normal canine liver was investigated. Selective embolisation was achieved by injecting TGMs into the left hepatic artery through a microcatheter in four healthy dogs. After embolisation, computed tomography (CT), biochemical analysis and histological examination were performed during a 12-week observation period. Embolisation was successful in all four dogs. Postoperative CT revealed consistent embolisation of the artery within the experimental period in three dogs. Hepatic enzyme levels slightly increased after embolisation but tapered to normal ranges. Histological examinations revealed no abnormal changes. Thus, selective TAE with TGMs was well tolerated in normal dogs and may be applicable to canine hepatocellular carcinoma. Highlights: Transcatheter arterial embolisation (TAE) plays a vital role in the treatment of hepatocellular carcinoma. Selective TAE with trisacryl gelatine microspheres (TGMs) was well tolerated in normal dogs. The embolization with TGMs was confirmed 12 weeks after treatment by post-embolisation computed tomography.