Emerging Involvement of long non-coding RNAs in gastrointestinal associated inflammatory disorders. (April 2020)

• Record Type: Journal Article
• Authors: Lashgarian, Hamed Esmaeil; Karkhane, Maryam; Marzban, Abdolrazagh; Yazdi, Mohammad; Shahzamani, Kiana
• Is Part Of: Comparative immunology, microbiology and infectious diseases. Volume 69(2020)
• Publication Date: 2020-04
• Subjects: Celiac -- IBD -- LncRNA -- Non-coding RNA -- Inflammatory disease -- Inflammatory bowel disease; Communicable diseases in animals -- Periodicals; Veterinary immunology -- Periodicals; Veterinary microbiology -- Periodicals; Immunology -- Periodicals; Microbiology -- Periodicals; Communicable diseases -- Periodicals; Communicable Diseases -- immunology -- Periodicals; Communicable Diseases -- veterinary -- Periodicals; Allergy and Immunology -- Periodicals; Microbiology -- Periodicals; Veterinary Medicine -- Periodicals; Immunologie -- Périodiques; Microbiologie -- Périodiques; Maladies infectieuses -- Périodiques; Communicable diseases; Immunology; Microbiology; Electronic journals; Periodicals; 636.08969
• DOI: 10.1016/j.cimid.2020.101428
• Languages: English
• ISSNs: 0147-9571

Abstract

Highlights: The possible function of lncRNAs in the modulation of gastrointestinal inflammatory pathways is addressed. Recent studies have confirmed the effectiveness of lncRNAs as a genetic factor in the development of inflammatory diseases. This review focuses on the function of lncRNA in gastrointestinal disorders, particularly IBD and celiac disorders, as two common gastrointestinal inflammatory disorders. Abstract: Gastrointestinal (GI) disorders including a wide range of infectious, inflammatory, autoimmune, etc. disorders. Inflammatory bowel and celiac disease are non-fatal but overwhelming GI associated disorders. IBD and celiac's complications, besides the great suffering, disturb the normal life of the patients and make them involved in mental and physical problems. The emerging role of genetic content is deniable for GI inflammatory disorders incidence, and long non-coding RNAs (lncRNAs) function is the recent topic for its association. Analyzing of absolute lncRNAs interference in GI inflammatory appearance remains in infancy, and more studies are requested. Here, we concisely performed a systematic review in the last knowledge up to 2020 to identify all of the significant lncRNAs associated with the initiation and progression of GI inflammatory diseases. Accordingly, this assay attempted to refer to the expression of lncRNAs changing from the normal state, discovery of genetic mechanisms, and main effectors that would trigger associated IBD and celiac expression and immune responses would be effective for therapeutic approaches. It could be useful for prognostic and diagnostic purposes of GI associated inflammatory disorders.