Pharmacokinetics and population pharmacokinetics in pediatric oncology. Issue 4 (25th December 2019)

• Record Type: Journal Article
• Authors: Sassen, Sebastiaan D.T.; Zwaan, C. Michel; van der Sluis, Inge M.; Mathôt, Ron A.A.
• Is Part Of: Pediatric blood & cancer. Volume 67:Issue 4(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-12-25
• Subjects: cancer pharmacology -- chemotherapy -- pediatric oncology -- pharmacokinetics -- pharmacology -- prediction modeling in cancer; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.28132
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract: Pharmacokinetic research has become increasingly important in pediatric oncology as it can have direct clinical implications and is a crucial component in individualized medicine. Population pharmacokinetics has become a popular method especially in children, due to the potential for sparse sampling, flexible sampling times, computing of heterogeneous data, and identification of variability sources. However, population pharmacokinetic reports can be complex and difficult to interpret. The aim of this article is to provide a basic explanation of population pharmacokinetics, using clinical examples from the field of pediatric oncology, to facilitate the translation of pharmacokinetic research into the daily clinic.