Correlation of 5‐HTR6 gene polymorphism with vestibular migraine. Issue 2 (6th October 2019)

• Record Type: Journal Article
• Authors: Wu, Xia; Qiu, Feng; Wang, Zhiwei; Liu, Bing; Qi, Xiaokun
• Is Part Of: Journal of clinical laboratory analysis. Volume 34:Issue 2(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-10-06
• Subjects: 5‐hydroxy tryptamine -- 5‐hydroxy tryptamine receptor 6 -- single nucleotide polymorphism -- vestibular function test -- vestibular migraine; Diagnosis, Laboratory -- Periodicals; Medical laboratory technology -- Periodicals; 616
• DOI: 10.1002/jcla.23042
• Languages: English
• ISSNs: 0887-8013

Abstract

Abstract: Objective: To investigate the correlation of 5‐hydroxy tryptamine receptor 6 (5‐HTR6) gene polymorphism with vestibular migraine (VM). Methods: A total of 92 VM patients were enrolled as the observation group, and 100 healthy people receiving physical examinations as the control group. Their general clinical information was collected, and the level of 5‐HT in plasma and the vestibular function test indexes were detected. Moreover, the polymorphism of 5‐HTR6 rs770963777 was detected with the TaqMan‐MGB probe. Results: The observation group had a lower level of 5‐HT than the control group ( P < .05), and the abnormality rates of the vestibular function tests, including the caloric test, head‐shaking test, and vestibular autorotation test, were obviously higher than those in the control group ( P < .01). The comparisons showed that the distribution frequencies of the genotypes and alleles were different between the two groups ( P < .05). According to the analysis of the genetic mode, there were differences in recessive and additive modes between the two groups ( P < .05), but the dominant mode was not different between the two groups ( P > .05). Conclusion: The level of 5‐HT and the vestibular function test indexes can serve as the effective indicators for observing VM, and the polymorphism of 5‐HTR6 rs770963777 site is correlated with VM onset.