Discovery of isoxazolyl-based inhibitors of Plasmodium falciparum cGMP-dependent protein kinase. Issue 1 (16th December 2019)

• Record Type: Journal Article
• Authors: Mahmood, Shams Ul; Cheng, Huimin; Tummalapalli, Sreedhar R.; Chakrasali, Ramappa; Yadav Bheemanaboina, Rammohan R.; Kreiss, Tamara; Chojnowski, Agnieska; Eck, Tyler; Siekierka, John J.; Rotella, David P.
• Is Part Of: MedChemComm. Volume 11:Issue 1(2020)
• Page Start: 98
• Page End: 101
• Publication Date: 2019-12-16
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19
• DOI: 10.1039/c9md00511k
• Languages: English
• ISSNs: 2040-2503

Abstract

Abstract : The cGMP-dependent protein kinase in Plasmodium falciparum (PfPKG) plays multiple roles in the life cycle of the parasite. Abstract : The cGMP-dependent protein kinase in Plasmodium falciparum (PfPKG) plays multiple roles in the life cycle of the parasite. As a result, this enzyme is a potential target for new antimalarial agents. Existing inhbitors, while potent and active in malaria models are not optimal. This communication describes initial optimization of a structurally distinct class of PfPKG inhibitors.