Dimerization of terminal alkynes promoted by a heterobimetallic Zr/Co complex. Issue 8 (5th February 2020)

• Record Type: Journal Article
• Authors: Beattie, Jeffrey W.; Wang, Canning; Zhang, Hongtu; Krogman, Jeremy P.; Foxman, Bruce M.; Thomas, Christine M.
• Is Part Of: Dalton transactions. Volume 49:Issue 8(2020)
• Page Start: 2407
• Page End: 2411
• Publication Date: 2020-02-05
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/d0dt00334d
• Languages: English
• ISSNs: 1477-9226

Abstract

Abstract : A reduced Zr IV /Co −I heterobimetallic complex facilitates the formation of 1, 3-enynes from terminal alkynes through a cooperative bimetallic C–H activation process. Abstract : Enynes are important synthetic intermediates that are also found in a variety of natural products and other biologically relevant molecules. The most atom economical synthetic route to enynes is via the direct coupling of readily available terminal alkyne precursors. Towards this goal, we demonstrate the formation of 1, 3-enynes from terminal alkynes facilitated by a reduced Zr IV /Co −I heterobimetallic complex. An intermediate is trapped as a t BuNC adduct, revealing that bimetallic activation of the terminal C–H bond of the alkyne is an essential mechanistic step.