An octopus-mimic PEGylated peptide as a specific integrin αvβ3 inhibitor for preventing tumor progression. Issue 14 (23rd January 2020)

• Record Type: Journal Article
• Authors: Shan, Xue; Zhang, Lei; Xu, Yurui; Sun, Lei; Guo, Leilei; Feng, Shujun; Ge, Haixiong; Gu, Tingting; Ning, Xinghai
• Is Part Of: Chemical communications. Volume 56:Issue 14(2020)
• Page Start: 2178
• Page End: 2181
• Publication Date: 2020-01-23
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc09496b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An integrin αvβ3 specific octopus mimicking peptide has been developed for enhancing tumor diagnosis and treatment. Abstract : We have developed a multivalent PEGylated RWrNR, named octopus-R, which exhibits good water solubility, biostability, biocompatibility and cancer targeting ability, endowing it with high anticancer potential. Octopus-R represents a promising theranostic agent and holds great potential for improving the management of malignant tumors.