Cilia oscillations. (30th December 2019)

• Record Type: Journal Article
• Authors: Man, Yi; Ling, Feng; Kanso, Eva
• Is Part Of: Philosophical transactions. Volume 375:Number 1792(2020)
• Publication Date: 2019-12-30
• Subjects: axoneme -- molecular motors -- microfilament deformation; Biology -- Periodicals; Science -- Periodicals; 570
• DOI: 10.1098/rstb.2019.0157
• Languages: English
• ISSNs: 0962-8436

Abstract

Abstract : Cilia, or eukaryotic flagella, are microscopic active filaments expressed on the surface of many eukaryotic cells, from single-celled protozoa to mammalian epithelial surfaces. Cilia are characterized by a highly conserved and intricate internal structure in which molecular motors exert forces on microtubule doublets causing cilia oscillations. The spatial and temporal regulations of this molecular machinery are not well understood. Several theories suggest that geometric feedback control from cilium deformations to molecular activity is needed. Here, we implement a recent sliding control model, where the unbinding of molecular motors is dictated by the sliding motion between microtubule doublets. We investigate the waveforms exhibited by the model cilium, as well as the associated molecular motor dynamics, for hinged and clamped boundary conditions. Hinged filaments exhibit base-to-tip oscillations while clamped filaments exhibit both base-to-tip and tip-to-base oscillations. We report the change in oscillation frequencies and amplitudes as a function of motor activity and sperm number, and we discuss the validity of these results in the context of experimental observations of cilia behaviour. This article is part of the Theo Murphy meeting issue 'Unity and diversity of cilia in locomotion and transport'.