Application of microphysiological systems in biopharmaceutical research and development. Issue 4 (22nd January 2020)

• Record Type: Journal Article
• Authors: Peterson, Norman C.; Mahalingaiah, Prathap Kumar; Fullerton, Aaron; Di Piazza, Matteo
• Is Part Of: Lab on a chip. Volume 20:Issue 4(2020)
• Page Start: 697
• Page End: 708
• Publication Date: 2020-01-22
• Subjects: Miniature electronic equipment -- Periodicals; Combinatorial chemistry -- Periodicals; Biotechnology -- Periodicals; 543.0813
• DOI: 10.1039/c9lc00962k
• Languages: English
• ISSNs: 1473-0197

Abstract

Abstract : In this review, we describe some of the advances made for tissue-specific microphysiological systems and outline the advantages and challenges of applying and further developing MPS technology in preclinical biopharmaceutical research. Abstract : Within the last 10 years, several tissue microphysiological systems (MPS) have been developed and characterized for retention of morphologic characteristics and specific gene/protein expression profiles from their natural in vivo state. Once developed, their utility is typically further tested by comparing responses to known toxic small-molecule pharmaceuticals in efforts to develop strategies for further toxicity testing of compounds under development. More recently, application of this technology in biopharmaceutical (large molecules) development is beginning to be more appreciated. In this review, we describe some of the advances made for tissue-specific MPS and outline the advantages and challenges of applying and further developing MPS technology in preclinical biopharmaceutical research.