Fsp3-rich and diverse fragments inspired by natural products as a collection to enhance fragment-based drug discovery. Issue 15 (27th January 2020)

• Record Type: Journal Article
• Authors: Hanby, Abigail R.; Troelsen, Nikolaj S.; Osberger, Thomas J.; Kidd, Sarah L.; Mortensen, Kim T.; Spring, David R.
• Is Part Of: Chemical communications. Volume 56:Issue 15(2020)
• Page Start: 2280
• Page End: 2283
• Publication Date: 2020-01-27
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc09796a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Herein, we describe the natural product inspired synthesis of 38 complex small molecules based upon 20 unique frameworks suitable for fragment-based screening. Abstract : Herein, we describe the natural product inspired synthesis of 38 complex small molecules based upon 20 unique frameworks suitable for fragment-based screening. Utilising an efficient strategy, two key building block diastereomers were harnessed to generate novel, three-dimensional fragments which each possess numerous synthetically accessible fragment growth positions.