Ratiometric detection of amyloid-β aggregation by a dual-emissive tris-heteroleptic ruthenium complex. Issue 14 (22nd January 2020)

• Record Type: Journal Article
• Authors: Shao, Jiang-Yang; Wu, Si-Hai; Ma, Junjie; Gong, Zhong-Liang; Sun, Tian-Ge; Jin, Yulong; Yang, Rong; Sun, Bin; Zhong, Yu-Wu
• Is Part Of: Chemical communications. Volume 56:Issue 14(2020)
• Page Start: 2087
• Page End: 2090
• Publication Date: 2020-01-22
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc08909h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A dual-emissive tris-heteroleptic ruthenium complex is reported for the ratiometric photoluminescent detection of amyloid-β aggregation in steady and transient states. Abstract : A dual-emissive tris-heteroleptic ruthenium complex is designed, synthesized and applied for the ratiometric photoluminescent detection of amyloid-β (Aβ) aggregation in both steady and transient states. The Aβ aggregation is supported by transmission electron microscopy and confocal laser scanning microscopy analysis. In addition, molecular docking calculations have been performed to gain insights into the interaction mode between the ruthenium complex and Aβ fibrils.