The effect of polydisperse fucoidans from Fucus vesiculosus on Hep G2 and Chang liver cells. (January 2020)

• Record Type: Journal Article
• Authors: Zhurishkina, Elena V.; Stepanov, Sergey I.; Ayrapetyan, Olga N.; Skorik, Yury A.; Vlasova, Elena N.; Kruchina-Bogdanov, Igor V.; Lebedev, Dmitry V.; Kulminskaya, Anna A.; Lapina, Irina M.
• Is Part Of: Bioactive carbohydrates and dietary fibre. Number 21(2020)
• Publication Date: 2020-01
• Subjects: Fucoidan -- Chang liver -- Hep G2; Functional foods -- Periodicals; Fiber in human nutrition -- Periodicals; Carbohydrates -- Periodicals; Glycoproteins -- Periodicals; Functional Food -- Periodicals; Dietary Fiber -- Periodicals; Carbohydrates -- Periodicals; Carbohydrates; Fiber in human nutrition; Functional foods; Glycoproteins; Periodicals; 613.28
• DOI: 10.1016/j.bcdf.2019.100209
• Languages: English
• ISSNs: 2212-6198

Abstract

Abstract: The effect of polydisperse fucoidans from brown algae Fucus vesiculosus on Hep G2 and Chang liver cells was studied. Despite the high molecular weight and polydispersity, these fucoidans exhibited antitumor activity, whereas the difference in the inhibitory effects on cell proliferation between the native and the partially hydrolyzed fucoidans was not statistically significant. Fucoidans were internalized by cells of both cell lines through endocytosis, with Chang liver cells metabolizing fucopolysaccharides more rapidly compared to the Hep G2. In both cell lines treatment with fucoidans was shown to induce apoptosis and autophagy, with apoptosis more pronounced in Hep G2 cells, whereas autophagy - in Chang liver cells. Graphical abstract: Image 1