Gemini basic ionic liquid as bi-functional catalyst for the synthesis of 2, 3-dihydroquinazolin-4(1H)-ones at room temperature. Issue 10 (5th March 2020)

• Record Type: Journal Article
• Authors: Dutta, Apurba; Damarla, Krishnaiah; Kumar, Arvind; Saikia, Prakash J.; Sarma, Diganta
• Is Part Of: Tetrahedron letters. Volume 61:Issue 10(2020)
• Publication Date: 2020-03-05
• Subjects: Green chemistry -- Gemini ionic liquids -- 2, 3-Dihydroquinazolin-4(1H)-ones -- Cascade synthesis; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2019.151587
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Bi-functional nature of the ionic liquid as catalyst cum solvent. Another benefit of the present strategy is avoiding conventional organic solvents. First room temperature protocol from 2-aminobenzonitriles and carbonyls. Some challenging aromatic ketones were utilized as substrates for the first time. Abstract: A cascade synthesis of 2, 3-dihydroquinazolin-4(1 H )-ones has been developed from 2-aminobenzonitriles and carbonyl analogues using Gemini basic ionic liquid as green catalyst cum solvent at room temperature. Both aldehydes and ketones were condensed with 2-aminobenzonitriles affording good to excellent yields of products. Moreover, the ionic liquids can be reused up to 5 th cycle without significant loss of catalytic activity.