Plasma proteomics of biomarkers for inflammation or cancer cannot predict relapse in chronic myeloid leukaemia patients stopping tyrosine kinase inhibitor therapy. (March 2020)

• Record Type: Journal Article
• Authors: Söderlund, Stina; Persson, Inger; Ilander, Mette; Guilhot, Joëlle; Hjorth-Hansen, Henrik; Koskenvesa, Perttu; Richter, Johan; Saussele, Susanne; Mustjoki, Satu; Olsson-Strömberg, Ulla
• Is Part Of: Leukemia research. Volume 90(2020)
• Publication Date: 2020-03
• Subjects: Chronic myeloid leukemia -- Tyrosine kinase inhibitor -- Treatment free remission -- Proteomics -- Immunology; Leukemia -- Periodicals; Leukemia -- Periodicals; Leucémie -- Périodiques; Leukemia; Periodicals; Electronic journals; Electronic journals; 616.9941905
• DOI: 10.1016/j.leukres.2020.106310
• Languages: English
• ISSNs: 0145-2126

Abstract

Highlights: Easily accessible biomarkers predicting successful TKI stop in CML needed. No predictive plasma protein markers found among 162 analysed proteins. Some protein markers higher in non-relapsing patients after TKI stop. A combination of clinical and biological factors needed for prediction of TFR. Abstract: Several studies have now shown that chronic myeloid leukaemia (CML) patients in deep molecular remission may discontinue tyrosine kinase inhibitor (TKI) treatment with a treatment free remission (TFR) rate of approximately 40–60 %. Some factors influencing the possibility of TFR have been described but better tools are needed for individual prediction of long-term TFR. Herein, two multiplex panels were utilised to analyse a total of 162 different plasma proteins from 56 patients included in the TKI stopping trial EURO-SKI (Saussele et al., 2018). The purpose was to identify possible plasma protein markers for prediction of successful TKI discontinuation and to evaluate effects of TKI discontinuation on plasma protein profiles. No protein biomarkers sampled before TKI discontinuation could separate relapse cases from non-relapse cases but some plasma proteins differed between patients who relapsed and those who remained in TFR when followed over time after TKI cessation. In conclusion, the plasma protein markers in this study could not predict relapse after TKI discontinuation but may be of use to understand the mechanisms involved in maintenance of TFR.