Study on the A3-coupling reaction catalyzed by readily available copper-containing minerals. Synthesis of propargylamines. Issue 10 (5th March 2020)

• Record Type: Journal Article
• Authors: Milen, Mátyás; Györke, Gábor; Dancsó, András; Volk, Balázs
• Is Part Of: Tetrahedron letters. Volume 61:Issue 10(2020)
• Publication Date: 2020-03-05
• Subjects: Copper-containing minerals -- Catalysis -- A3-coupling -- Multicomponent reaction; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2019.151544
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Application of copper-containing mineral catalysts in organic synthesis. A novel strategy in the field of Cu-catalyzed organic reactions. Efficient synthesis of propargylamines. Abstract: The highly atom efficient three-component reaction of aldehydes, secondary amines and acetylenes to form propargylamines (A 3 -coupling) has been studied with twelve readily available copper-containing minerals. It was found that the reaction could easily be performed in the presence of malachite, brochantite, chrysocolla and azurite in toluene at reflux. The desired products were obtained in good to excellent yields.