Facial conversion of secondary phosphine oxides R1R2P(O)H to chlorophosphines R1R2PCl by acetyl chloride. Issue 10 (5th March 2020)

• Record Type: Journal Article
• Authors: Zhang, Jian-Qiu; Yang, Shangdong; Han, Li-Biao
• Is Part Of: Tetrahedron letters. Volume 61:Issue 10(2020)
• Publication Date: 2020-03-05
• Subjects: Chlorophosphines -- Secondary phosphine oxides -- Reductive conversion -- Acyl chloride; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2019.151556
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Secondary phosphine oxides to chlorophosphines. Using AcCl instead of PCl3. High yields, easy purification. Abstract: A practically useful protocol for the reductive transformation of secondary phosphine oxides R 1 R 2 P(O)H to chlorophosphines R 1 R 2 PCl using acetyl chloride was disclosed. Various secondary phosphine oxides could be readily reduced to the corresponding chlorophosphines in high yields under mild conditions.