TEMPO-mediated cross dehydrogenative coupling aminomethylation of imidazopyridine. Issue 10 (5th March 2020)

• Record Type: Journal Article
• Authors: Wang, Jingcai; Leng, Yuting; Hu, Zongqiang; Pan, Yuping; Wang, Shiwei; Wu, Yangjie
• Is Part Of: Tetrahedron letters. Volume 61:Issue 10(2020)
• Publication Date: 2020-03-05
• Subjects: Imidazopyridines -- 3-Dimethylaminopropionitrile -- Aminomethylation -- Dehydrogenative coupling; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2019.151590
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Direct aminomethylation of imidazopyridine with 3-dimethylaminopropionitrile. The reaction showed good functional group tolerance at room temperature. Clean reaction, ease of product isolation and a simple experimental procedure. Abstract: An efficient approach for the direct aminomethylation of imidazo[1, 2– a ]pyridine with 3-dimethylaminopropionitrile has been realized at room temperature. This methodology has several advantages: (1) using efficient manganese (III) and inexpensive K2 S2 O8 as oxidants, (2) mild reaction conditions, (3) good functional group tolerance for 26 examples. An array of aminomethylated imidazopyridines broad functionalities were obtained in good to excellent yields.