In vitro leishmanicidal activity of copper (II) 5, 7-dimethyl-1, 2, 4-triazolo[1, 5-a]pyrimidine complex and analogous transition metal series. (15th January 2020)

• Record Type: Journal Article
• Authors: Méndez-Arriaga, José M.; Rodríguez-Diéguez, Antonio; Sánchez-Moreno, Manuel
• Is Part Of: Polyhedron. Volume 176(2020)
• Publication Date: 2020-01-15
• Subjects: Triazolopyrimidine -- Coordination chemistry -- Antiparasitic activity -- Leishmania -- Structure description; Chemistry, Inorganic -- Periodicals; Chimie inorganique -- Périodiques; Organometaalverbindingen; Anorganische chemie; 546.05
• DOI: 10.1016/j.poly.2019.114272
• Languages: English
• ISSNs: 0277-5387

Abstract

Graphical abstract: Four 5, 7-dimethyl-1, 2, 4-triazolo[1, 5- a ]pyrimidine Cu(II), Co(II), Ni(II) and Zn(II) complexes have been synthesized and characterized by X-ray diffraction, spectroscopic and thermal analysis. In vitro antiparasitic activity of the complexes against four Leishmania spp. strains was tested. SI values significantly higher than drug reference and isolated ligand have been obtained, especially for Ni(II). Abstract: A series of triazolopyrimidine transition metals complexes have been synthesized by the reaction between the derivative 5, 7-dimethyl-1, 2, 4-triazolo[1, 5- a ]pyrimidine (dmtp ) with M(NO3 )2 ·XH2 O (M = Cu(II), Co(II), Ni(II) and Zn(II)). These four compounds have been characterized by spectroscopic and thermal analysis and the crystal structure of the Cu(II) one has been solved by X-ray diffraction methods. The in vitro antiparasitic activity of these complexes against four leishmania spp. strands and their toxicity against macrophage host cells have also been studied, in order to elucidate the influence of different metal centres in the leishmanicidal effect to fight neglected tropical diseases.