Plasma miR-10a: A Potential Biomarker for Coronary Artery Disease. (22nd May 2016)

• Record Type: Journal Article
• Authors: Luo, Liyun; Chen, Bairong; Li, Songbiao; Wei, Xiaoliang; Liu, Tianmin; Huang, Yin; Lin, Xiufang
• Other Names: Sobrino Tomás Academic Editor.
• Is Part Of: Disease markers. Volume 2016(2016)
• Publication Date: 2016-05-22
• Subjects: Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2016/3841927
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Aims . MicroRNAs (miRNAs) are involved in the pathogenesis of coronary artery disease (CAD). The objective of this study is to determine plasma levels of miR-10a in CAD and analyze its association with the severity of CAD. Materials and Methods . Plasma miR-10a levels in 60 CAD patients including stable angina pectoris (SAP) (n = 29 ), unstable angina pectoris (UAP) or non-ST elevation myocardial infarction (MI) (NSTEMI) (n = 17 ), or ST elevation MI (STEMI) (n = 14 ) and 20 non-CAD subjects were assessed by real-time polymerase chain reaction (qRT-PCR), and associations of miR-10a levels with risk factors of CAD and its severity were analyzed. Results . The qRT-PCR results showed that plasma miR-10a levels were decreased in CAD patients, and CAD with high SYNTAX scores or STEMI was significantly associated with lower miR-10a levels. Conclusions . Lower plasma miR-10a levels were negatively associated with the presence as well as severity of CAD, and plasma miR-10a can act as a potential biomarker for estimating the presence and severity of CAD.