Potential Applications of 68Ga-PSMA-11 PET/CT in the Evaluation of Salivary Gland Uptake Function: Preliminary Observations and Comparison with 99mTcO4− Salivary Gland Scintigraphy. (11th January 2020)

• Record Type: Journal Article
• Authors: Zhao, Yanhong; Xia, Yuxiao; Liu, Huipan; Wang, Zi; Chen, Yue; Zhang, Wei
• Other Names: Vali Reza Academic Editor.
• Is Part Of: Contrast media & molecular imaging. Volume 2020(2020)
• Publication Date: 2020-01-11
• Subjects: Diagnostic imaging -- Periodicals; Magnetic resonance imaging -- Periodicals; Contrast media (Diagnostic imaging) -- Periodicals; Contrast Media -- Periodicals; Diagnostic Imaging -- Periodicals; Substances de contraste -- Périodiques; Diagnostics moléculaires -- Périodiques; Imagerie médicale; Substance de contraste; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.0754
• DOI: 10.1155/2020/1097516
• Languages: English
• ISSNs: 1555-4309

Abstract

Abstract : Purpose . To preliminarily evaluate the feasibility and potential of using 68 Ga-PSMA-11 PET/CT in evaluating the function of salivary glands and lacrimal glands in comparison with 99m Tc-pertechnetate (T 99 m cO 4 − ) salivary gland scintigraphy (SGS). Methods . A retrospective study was performed in 15 patients with different degrees of xerostomia and suspected salivary gland dysfunction. Each patient underwent 68 Ga-PSMA-11 PET/CT first and SGS the next day, and the findings of both scans were compared. Results . The results of 68 Ga-PSMA-11 PET/CT and SGS were consistent in 12/15 patients (80%) and were inconsistent in the remaining patients (20%). For 5 (33.3%) of 15 patients, 68 Ga-PSMA-11 PET/CT provided more information than did SGS. Additionally, 68 Ga-PSMA-11 PET/CT corrected the misdiagnosis by SGS for 1 patient. Conclusions . 68 Ga-PSMA-11 PET/CT is a potentially useful imaging tool for evaluating the function of salivary glands and lacrimal glands. 68 Ga-PSMA-11 PET/CT can be a promising supplement to SGS, and its clinical value deserves further study.