TiCl4 mediated facile synthesis of 1, 3, 4-oxadiazoles and 1, 3, 4-thiadiazoles. Issue 3 (1st February 2020)

• Record Type: Journal Article
• Authors: Zhang, Lin; Yu, Yu; Tang, Qiang; Yuan, Jianyong; Ran, Dongzhi; Tian, Binghua; Pan, Tao; Gan, Zongjie
• Is Part Of: Synthetic communications. Volume 50:Issue 3(2020)
• Page Start: 423
• Page End: 431
• Publication Date: 2020-02-01
• Subjects: 1, 3, 4-oxadiazoles and 1, 3, 4-thiadiazoles -- synthesis -- TiCl4; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2019.1700521
• Languages: English
• ISSNs: 0039-7911

Abstract

Abstract: An efficient method for the synthesis of 2, 5-disubstituted 1, 3, 4-oxadiazoles and 1, 3, 4-thiadiazoles has been developed. Various hydrazides or thionyl hydrazides readily react with DMA derivatives in the presence of TiCl4 as a catalyst to afford the desired products. This protocol provides a simple and economical procedure that affords the target products with good yields and wide substrate scope. GRAPHICAL ABSTRACT: