Inflammation in deep vein thrombosis: a therapeutic target?. Issue 1 (1st January 2019)

• Record Type: Journal Article
• Authors: Borgel, Delphine; Bianchini, Elsa; Lasne, Dominique; Pascreau, Tiffany; Saller, François
• Is Part Of: Hematology. Volume 24:Issue 1(2019)
• Page Start: 742
• Page End: 750
• Publication Date: 2019-01-01
• Subjects: Deep vein thrombosis -- inflammation -- post-thrombotic syndrome -- DOAC -- heparin -- neutrophil extracellular traps (NETs) -- P-selectin -- CRP; Blood -- Diseases -- Periodicals; Hematology -- Periodicals; Blood -- Transfusion -- Periodicals; 616.15005
• DOI: 10.1080/16078454.2019.1687144
• Languages: English
• ISSNs: 1024-5332

Abstract

ABSTRACT: Deep vein thrombosis is a common disease associated with a variety of complications including post-thrombotic syndrome as a late complication. It is now clear that in addition to classical deep vein thrombosis triggers such as blood flow disturbance, hypercoagulability, and vessel wall changes, inflammation has a key role in the pathophysiology of deep vein thrombosis, and there is a close relationship between inflammation and coagulation. As attested by changes in several plasma biomarkers, inflammation may have a significant role in the development of post-thrombotic syndrome. Here, we review the link between inflammation and deep vein thrombosis and thus the potential value of anti-inflammatory and/or anticoagulant drugs in the treatment of deep vein thrombosis and the prevention of post-thrombotic syndrome.