Lessons From Influenza Pandemics of the Last 100 Years. (17th August 2019)

• Record Type: Journal Article
• Authors: Monto, Arnold S; Fukuda, Keiji
• Is Part Of: Clinical infectious diseases. Volume 70:Number 5(2020)
• Page Start: 951
• Page End: 957
• Publication Date: 2019-08-17
• Subjects: influenza -- influenza pandemic history -- pandemic preparedness -- influenza vaccines -- influenza control; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciz803
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract : Despite the major burden of seasonal influenza, only the threat of pandemics is of universal concern globally. Past pandemics are reviewed, identifying measures that will be of value going forward. These will also help in controlling seasonal influenza. Abstract: Seasonal influenza is an annual occurrence, but it is the threat of pandemics that produces universal concern. Recurring reports of avian influenza viruses severely affecting humans have served as constant reminders of the potential for another pandemic. Review of features of the 1918 influenza pandemic and subsequent ones helps in identifying areas where attention in planning is critical. Key among such issues are likely risk groups and which interventions to employ. Past pandemics have repeatedly underscored, for example, the vulnerability of groups such as pregnant women and taught other lessons valuable for future preparedness. While a fundamental difficulty in planning for the next pandemic remains their unpredictability and infrequency, this uncertainty can be mitigated, in part, by optimizing the handling of the much more predictable occurrence of seasonal influenza. Improvements in antivirals and novel vaccine formulations are critical in lessening the impact of both pandemic and seasonal influenza.