A Novel, High-sensitivity, Bacteriophage-based Assay Identifies Low-level Mycobacterium tuberculosis Bacteremia in Immunocompetent Patients With Active and Incipient Tuberculosis. (22nd June 2019)

• Record Type: Journal Article
• Authors: Verma, Raman; Swift, Benjamin M C; Handley-Hartill, Wade; Lee, Joanne K; Woltmann, Gerrit; Rees, Catherine E D; Haldar, Pranabashis
• Is Part Of: Clinical infectious diseases. Volume 70:Number 5(2020)
• Page Start: 933
• Page End: 936
• Publication Date: 2019-06-22
• Subjects: bacteriophage -- bacteremia -- human tuberculosis -- blood; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciz548
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: The haematogenous dissemination of Mycobacterium tuberculosis (Mtb) is critical to the pathogenesis of progressive tuberculous infections in animal models. Using a novel, phage-based blood assay, we report the first concordant evidence in well-characterized, immunocompetent human cohorts, demonstrating associations of Mtb bacteremia with progressive phenotypes of latent infection and active pulmonary tuberculosis.