In silico molecular docking and in vitro antioxidant activity studies of novel α-aminophosphonates bearing 6-amino-1, 3-dimethyl uracil. (3rd March 2020)

• Record Type: Journal Article
• Authors: Nayab, Rasool Shaik; Maddila, Suresh; Krishna, Murthy Potla; Salam, J. J. Titinchi; Thaslim, Basha Shaik; Chintha, Venkataramaiah; Wudayagiri, Rajendra; Nagam, Venkateswarlu; Tartte, Vijaya; Chinnam, Sampath; Chamarthi, Naga Raju
• Is Part Of: Journal of receptor and signal transduction research. Volume 40:Number 2(2020)
• Page Start: 166
• Page End: 172
• Publication Date: 2020-03-03
• Subjects: Molecular docking studies -- antioxidant activity -- Eaton's reagent -- green synthesis -- α-aminophosphonates; Cell receptors -- Periodicals; Cellular signal transduction -- Periodicals; 571.6
• DOI: 10.1080/10799893.2020.1722166
• Languages: English
• ISSNs: 1079-9893

Abstract

Abstract: In the present study, a new series of α -Aminophosphonates bearing 6-amino-1, 3-dimethyluracil was synthesized in good to excellent yields (78–95%) by one-pot, three-component reaction of 6-amino-1, 3-dimethyluracil, aromatic aldehydes and diethylphosphite via Kabachnik–Fields reaction by using an eco-friendly Eaton's reagent. All the compounds were screened for in vitro antioxidant studies by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and hydrogen peroxide (H2 O2 ) methods. Among the synthesized bioactive molecules, 4a, 4d, 4g, and 4h exhibited promising antioxidant activity compared with the standard drug Ascorbic acid. Furthermore, in order to support the biological results of the compounds, molecular docking studies were performed against Aromatase enzyme for four compounds which revealed that the compounds 4a, 4d, 4g, and 4h have significant binding modes, with docking scores of −8.6, −8.4, −8.1 and −8.1 respectively and the compound 4b specifically has equal dock score of −8.0 when compared with the standard drug Exemestane.