Hepatic protective effects of sulforaphane through the modulation of inflammatory pathways. Issue 4 (2nd April 2020)

• Record Type: Journal Article
• Authors: Lee, Changhun; Yang, Sumin; Lee, Bong-Seon; Jeong, So Yeon; Kim, Kyung-Min; Ku, Sae-Kwang; Bae, Jong-Sup
• Is Part Of: Journal of Asian natural products research. Volume 22:Issue 4(2020)
• Page Start: 386
• Page End: 396
• Publication Date: 2020-04-02
• Subjects: Sulforaphane -- liver failure -- inflammation -- toll-like receptor -- lipopolysaccharide; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2019.1581174
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: The aim of this study was to investigate the effects of sulforaphane (SFN) on lipopolysaccharide (LPS)-induced liver failure, and to elucidate underlying mechanisms. SFN, a natural isothiocyanate present in cruciferous vegetables such as broccoli and cabbage, is effective in preventing carcinogenesis, diabetes, and inflammatory responses. Mice were treated intravenously with SFN at 12 h after LPS treatment. LPS significantly increased mortality, serum levels of liver damage markers, and inflammatory cytokines, and toll-like receptor 4 (TLR4) protein expression, which were reduced by SFN. Our results suggest that SFN protects against LPS-induced liver damage, indicating its potential to treat liver diseases. Graphical Abstract: