Two novel non-holostane type glycosides from the viscera of sea cucumber Apostichopus japonicus. Issue 4 (2nd April 2020)

• Record Type: Journal Article
• Authors: Zhang, Xuan-Ming; Han, Li-Wen; Sheng, Wen-Long; Li, Xiao-Bin; Zhang, Shan-Shan; Guo, Jing-Lan; Lin, Hou-Wen; Liu, Ke-Chun
• Is Part Of: Journal of Asian natural products research. Volume 22:Issue 4(2020)
• Page Start: 329
• Page End: 337
• Publication Date: 2020-04-02
• Subjects: Apostichopus japonicus -- viscera -- non-holostane -- glycosides -- structural identification -- antitumor; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2019.1576643
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Two novel glycosides, apostichoposide A1 (1 ) and B1 (2 ), were isolated from the viscera of Chinese sea cucumbers ( Apostichopus japonicus, Selenka) collected in the Bohai sea. Both the isolated glycosides were characterized by non-holostane type aglycones having 18(16)-lactone and 7(8)-double bond. Cytotoxic activities of the two compounds were evaluated against three human cancer cell lines. Compound 1 had adequate cytotoxic activity against MGC-803 and PC-3M cell lines. Our results indicated that glycosides present in A. japonicus viscera are an important high value resource for biotechnological applications. Graphical Abstract: