A 'light-up' intercalator displacement assay for detection of triplex DNA stabilizers. Issue 13 (21st January 2020)
- Record Type:
- Journal Article
- Title:
- A 'light-up' intercalator displacement assay for detection of triplex DNA stabilizers. Issue 13 (21st January 2020)
- Main Title:
- A 'light-up' intercalator displacement assay for detection of triplex DNA stabilizers
- Authors:
- del Mundo, Imee M. A.
Cho, Eun Jeong
Dalby, Kevin N.
Vasquez, Karen M. - Abstract:
- Abstract : A 'light-up' intercalator displacement assay to detect binding of triplex ligands was developed and assessed for high-throughput screening applicability. Abstract : Here, we developed a coralyne-based, 'light-up' intercalator displacement assay to identify molecular stabilizers of triplex DNA using a sequence from a chromosomal breakpoint hotspot in the human c-MYC oncogene. Its potential to identify triplex DNA ligands was demonstrated using BePI and doxorubicin. Identification of triplex-interacting ligands may allow the regulation of genetic instability in human genomes.
- Is Part Of:
- Chemical communications. Volume 56:Issue 13(2020)
- Journal:
- Chemical communications
- Issue:
- Volume 56:Issue 13(2020)
- Issue Display:
- Volume 56, Issue 13 (2020)
- Year:
- 2020
- Volume:
- 56
- Issue:
- 13
- Issue Sort Value:
- 2020-0056-0013-0000
- Page Start:
- 1996
- Page End:
- 1999
- Publication Date:
- 2020-01-21
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c9cc08817b ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 12893.xml