Silk/polyols/GOD microneedle based electrochemical biosensor for continuous glucose monitoring. Issue 11 (10th February 2020)

• Record Type: Journal Article
• Authors: Zhao, Liang; Wen, Zhuangzhuang; Jiang, Fujian; Zheng, Zhaozhu; Lu, Shenzhou
• Is Part Of: RSC advances. Volume 10:Issue 11(2020)
• Page Start: 6163
• Page End: 6171
• Publication Date: 2020-02-10
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c9ra10374k
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : This work illustrates the feasibility of a microneedle based electrochemical biosensor for continuous glucose monitoring. Abstract : This work illustrates the feasibility of a microneedle based electrochemical biosensor for continuous glucose monitoring. The device consists of three silk/d -sorbitol pyramidal microneedles integrated with platinum (Pt) and silver (Ag) wires and immobilized glucose selective enzyme (glucose oxidase, GOD) during fabrication. The silk/d -sorbitol composite can provide a biocompatible environment for the enzyme molecules. The break strength can be controlled by the ratio of silk to d -sorbitol, which guarantees microneedle penetrate into skin. The enzymatic-amperometric responses and glucose concentration were linearly correlated, and cover physiological conditions. The microneedle displays high stability both in long-term monitoring and storage, even at 37 °C. Our results reveal that this new microneedle biosensor is a promising tool for wearable minimally invasive continuous glucose monitoring in practical applications.