Drug Screen Tugs at Common Thread for Repeat Disorders. (February 2020)

• Record Type: Journal Article
• Authors: Reddy, Kaalak; Cleary, John Douglas; Berglund, J. Andrew
• Is Part Of: Trends in pharmacological sciences. Volume 41:Number 2(2020)
• Page Start: 71
• Page End: 73
• Publication Date: 2020-02
• Subjects: RAN translation -- therapeutic compound screen -- RNA binding -- multiple targets; Pharmacology -- Periodicals; Pharmacology -- trends -- Periodicals; Pharmacologie -- Périodiques; Pharmacology; Electronic journals; Periodicals; 615.1
• DOI: 10.1016/j.tips.2019.12.004
• Languages: English
• ISSNs: 0165-6147

Abstract

Abstract : Repeat-associated non-ATG (RAN) translation is emerging as a driver of pathogenesis in microsatellite expansion disorders. Green and colleagues recently identified several candidate RAN translation inhibitors from a high-throughput small-molecule screen for fragile X tremor ataxia syndrome. Their study establishes a path forward for identifying inhibitors of RAN translation for multiple disorders.