The convergent procedure versus catheter ablation alone in longstanding persistent atrial fibrillation: A single centre, propensity-matched cohort study. (15th March 2020)

• Record Type: Journal Article
• Authors: Maclean, E.; Yap, J.; Saberwal, B.; Kolvekar, S.; Lim, W.; Wijesuriya, N.; Papageorgiou, N.; Dhillon, G.; Hunter, R.J.; Lowe, M.; Lambiase, P.; Chow, A.; Abbas, H.; Schilling, R.; Rowland, E.; Ahsan, S.
• Is Part Of: International journal of cardiology. Volume 303(2020)
• Page Start: 49
• Page End: 53
• Publication Date: 2020-03-15
• Subjects: Persistent atrial fibrillation -- Hybrid surgical ablation -- Convergent procedure -- Catheter ablation; Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2019.10.053
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Background: Maintenance of sinus rhythm is challenging in patients with longstanding persistent atrial fibrillation (PeAF). Minimally invasive surgical AF ablation may improve outcomes when combined with catheter ablation (the 'convergent' procedure). This study evaluates the safety and efficacy of the convergent procedure versus catheter ablation alone in longstanding PeAF. Methods: 43 consecutive patients with longstanding PeAF underwent subxiphoid endoscopic ablation of the posterior left atrium followed by catheter ablation from 2013 to 2018. The primary outcome was AF-free survival at 12 months; secondary outcomes included change in EHRA class, echocardiographic data, procedural complications, freedom from anti-arrhythmic drugs (AADs), and long term arrhythmia-free survival. Outcomes were compared with a matched group of 43 patients who underwent catheter ablation alone. Both groups underwent multiple catheter ablations as required. Baseline characteristics were similar between groups. Results: After 12 months, the convergent procedure was associated with increased AF-free survival on AADs (60.5% versus 25.6%, p = .002) and off AADs (37.2% versus 13.9%, p = .025), versus catheter ablation. Allowing for multiple procedures, after 30.5 ± 13.3 months' follow-up the convergent procedure was associated with increased arrhythmia-free survival on AADs (58.1% versus 30.2%, p = .016) and off AADs (32.5% versus 11.6%, p = .036) versus catheter ablation. There were more complications in the convergent procedure group (11.6% versus 2.3%, p = .2). Multivariate analysis identified only the convergent procedure (OR 3.06 (1.23–7.6), p = .017) as predictive of arrhythmia-free survival long term. Conclusions: In longstanding PeAF, the convergent procedure is associated with improved arrhythmia-free survival versus catheter ablation alone. Complication rates are significant but have been shown to depreciate with experience. Highlights: 43 patients with longstanding persistent AF underwent the convergent procedure. 43 matched controls underwent catheter ablation alone. The convergent procedure was associated with improved arrhythmia-free survival. There was a trend towards more complications in the convergent group.