P816 Association of autoimmune rheumatic disease with inflammatory bowel disease: a nationwide population-based study. (15th January 2020)

• Record Type: Journal Article
• Authors: Baek, D; Lee, H S; Park, S B; Song, H K; Jang, B I; Bae, J H; Goong, H J; Kang, H S; Jung, S H; Kim, T O; Song, G A; Park, E Y
• Is Part Of: Journal of Crohn's and colitis. Volume 14(2020)Supplement 1
• Page Start: S635
• Page End: S636
• Publication Date: 2020-01-15
• Subjects: Inflammatory bowel diseases -- Periodicals; 616.344005
• DOI: 10.1093/ecco-jcc/jjz203.944
• Languages: English
• ISSNs: 1873-9946

Abstract

Abstract: Background: Increasing evidence demonstrated that inflammatory bowel disease (IBD) has a shared genetic background with autoimmune rheumatic diseases (ARDs). However, the association between these two disease entities is not vigorously elucidated. The aim of this study is to investigate the prevalence and association between IBD and ARDs. Methods: A nationwide population-based cross-sectional study was performed using the Korean National Health Insurance Claims database according to ICD-10 codes (Table 1). The prevalence of ARDs, including systemic lupus erythematosus (SLE), inflammatory myositis (polymyositis (PM) and dermatomyositis (DM)), systemic sclerosis (SSc), Sjogren's syndrome (SjS), ankylosing spondylitis (AS), and rheumatoid arthritis (RA), was determined in patients with inflammatory bowel disease, compared with general populations. Results: A total of 82, 480 IBD patients (57, 382 patients with ulcerative colitis and 25, 098 with Crohn's disease) were enrolled. The analysis revealed that patient with IBD had higher risk of being concomitantly affected by AS and RA (Table 2). Other ARDs, such as SLE, inflammatory myositis, SSc, and SjS were not associated with IBD. Conclusion: This nationwide population-based study demonstrated that RA and AS showed higher incidence in IBD patients. This result suggests that etiopathogenesis of IBD might be shared with RA and AS.